Sometimes a lower level position in a large company with room for growth is a great way to get in, demonstrate your abilities, and get promoted, whereas getting into a small company where you will never have the opportunity to advance is not advantageous to your resume and your career.
Ask targeted questions in the interview. Find out if the position/company have room to grow. Talk to others at the company. Utilize www.linkedin.com and the web to see what others think of the internal workings of the company.
Don't just take an opportunity at face value: dig deeper, ask more, and identify if the role is the one for you or if you would be wasting time.