Absolutely! I had many candidates pass on interviews and lose out on jobs because they had family in town, and guess what? The candidates who were available got the job! Companies are looking at budgets and headcounts for the following year. People resign around the clock. Companies assess how they are doing and realize that they are looking for more people the following calendar year. If you really want to stand out and make a difference, leave Uncle Johnny and Aunt Susie at home for a few (or better yet, drop them at the mall), and go spend an hour in an interview. It will set you apart from the competition and really make a strong impact! Be the one who is available. Your competition is traveling, shopping, and baking!
As an aside, temporary help is at an all time high during the holidays, and is great for a little extra cash!